Interleukine 10

IL10
Structure cristalline de l'IL-10 telle que publiée dans la Protein Data Bank (PDB : 2H24)
Structures disponibles PDB Recherche d'orthologue: PDBe RCSB Identifiants PDB 1ILK, 1INR, 1J7V, 1LK3, 1Y6K, 2ILK, 2H24
Identifiants
Aliases	IL10, human cytokine synthesis inhibitory factor, Interleukine 10, CSIF
IDs externes	OMIM: 124092 MGI: 96537 HomoloGene: 478 GeneCards: IL10
Position du gène (Homme) Chr. Chromosome 1 humain[1] Locus 1q32.1 Début 206,767,602 bp[1] Fin 206,774,541 bp[1]
Position du gène (Souris) Chr. Chromosome 1 (souris)[2] Locus 1 E4|1 56.89 cM Début 130,947,582 bp[2] Fin 130,952,711 bp[2]
Expression génétique Bgee Humain Souris (orthologue) Fortement exprimé dans appendice iléo-cæcal vésicule biliaire cartilage tissue rate left uterine tube ganglion lymphatique muqueuse gastrique right adrenal cortex left adrenal cortex granulocyte Fortement exprimé dans embryon embryon lumbar subsegment of spinal cord stroma of bone marrow Cortex entorhinal Épiblaste lumbar spinal ganglion thymus tracheobronchial tree strie vasculaire Plus de données d'expression de référence BioGPS Plus de données d'expression de référence
Gene Ontology Fonction moléculaire liaison protéique growth factor activity cytokine activity interleukin-10 receptor binding protein dimerization activity Composant cellulaire région extracellulaire milieu extracellulaire Processus biologique negative regulation of chronic inflammatory response to antigenic stimulus positive regulation of MHC class II biosynthetic process negative regulation of endothelial cell apoptotic process hématopoïèse negative regulation of interferon-gamma production regulation of sensory perception of pain positive regulation of B cell apoptotic process negative regulation of chemokine (C-C motif) ligand 5 production response to inactivity negative regulation of cytokine activity negative regulation of interleukin-1 production cellular response to hepatocyte growth factor stimulus cellular response to estradiol stimulus negative regulation of interleukin-6 production vieillissement positive regulation of DNA-binding transcription factor activity negative regulation of apoptotic process negative regulation of cytokine production involved in immune response response to glucocorticoid cytoplasmic sequestering of NF-kappaB negative regulation of interleukin-18 production negative regulation of MHC class II biosynthetic process response to activity response to organic substance response to carbon monoxide leukocyte chemotaxis type 2 immune response negative regulation of myeloid dendritic cell activation response to insulin negative regulation of interleukin-8 production response to lipopolysaccharide B cell proliferation negative regulation of T cell proliferation negative regulation of nitric oxide biosynthetic process branching involved in labyrinthine layer morphogenesis defense response to bacterium regulation of complement-dependent cytotoxicity réponse immunitaire régulation de l'expression des gènes B cell differentiation regulation of isotype switching negative regulation of tumor necrosis factor production negative regulation of membrane protein ectodomain proteolysis réponse inflammatoire cellular response to lipopolysaccharide negative regulation of B cell proliferation negative regulation of inflammatory response negative regulation of cytokine production positive regulation of transcription by RNA polymerase II negative regulation of interleukin-12 production defense response to protozoan negative regulation of sensory perception of pain positive regulation of macrophage activation régénération du foie regulation of synapse organization positive regulation of endothelial cell proliferation negative regulation of cell population proliferation negative regulation of heterotypic cell-cell adhesion positive regulation of heterotypic cell-cell adhesion positive regulation of cell cycle negative regulation of mitotic cell cycle endothelial cell apoptotic process regulation of response to wounding negative regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell proliferation interleukin-12-mediated signaling pathway régulation positive de la transcription dépendante de l'ADN negative regulation of autophagy cytokine-mediated signaling pathway positive regulation of receptor signaling pathway via JAK-STAT positive regulation of pri-miRNA transcription by RNA polymerase II negative regulation of hydrogen peroxide-induced neuron death positive regulation of sprouting angiogenesis Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 3586 16153 Ensembl ENSG00000136634 ENSMUSG00000016529 UniProt P22301 P18893 RefSeq (mRNA) NM_000572 NM_010548 RefSeq (protéine) NP_000563 NP_034678 Localisation (UCSC) Chr 1: 206.77 – 206.77 Mb Chr 1: 130.95 – 130.95 Mb Publication PubMed [3] [4]
Wikidata
Voir/Editer Humain Voir/Editer Souris

L'Interleukine 10 (IL10), parfois appelé CSIF (de l'anglais : human cytokine synthesis inhibitory factor) est une protéine produite par différentes cellules sanguines et agissant en diminuant la réponse immunitaire. Son gène est le IL10 situé sur le chromosome 1 humain.

C'est aussi une cytokine produite par les cellules dendritiques et les macrophages qui permet la différenciation des lymphocytes TCD4 en lymphocyte T régulateur.